The success with chimeric antigen receptor T cells (CAR-T cells) has reinvigorated interest in T cells and their natural recognition of target antigens. Many researchers are interested in antigen-specific T cells for developing T cell receptor-based therapies, which was a big topic at the ASCO Annual Meeting last month.
With so much demand for antigen-specific T cells from pharmaceutical companies to academic research labs, we have developed several antigen-specific T cell lines over the years, most of which are exclusive products you’ll only find at Astarte.
Excellence in Antigen-Specific T Cells
Our scientists are some of the most experienced in the culture of antigen-specific T cells. We’ve been developing these specialized cells for customers and commercial availability for several years, and it’s a niche we are excited to serve.
Our lab produces both CD4+ and CD8+ antigen-specific T cells in several categories. These cells tend to sell out very fast, so you may not always find them in our inventory. But you can always inquire about cell availability or submit a custom request for our scientists to develop an antigen-specific T cell line for your research. We have developed:
- Autoimmune-Specific T Cells (MBP)
- Drug-Specific T Cells (Glatiramer Acetate)
- Virus-Specific T Cells (CMV, Influenza, HPV, EBV)
- Bacteria-Specific T Cells (Tetanus Toxoid)
- Tumor-Specific T Cells (WT1)
How Astarte Can Help You
Our scientists are skilled at all aspects of developing antigen-specific T cells and custom assays. Here are some of the things we can do for you when you contact us with an antigen-specific T cell request.
Selecting the Best Epitope
We utilize the Immune Epitope Database and its epitope prediction tool to research epitopes that have been published and find targets that haven’t been published. We also perform a comprehensive literature review for fuller understanding of epitope selection.
Screening Donors for Reactivity
With hundreds of unique donors in our database, we have access to cells from donors of various ages, genders, and disease states. We choose donors who are reactive to the target antigen and match any other requirements you have.
Generating Antigen-Specific T Cell Lines
We specialize in developing T cell lines that recognize specific peptide antigens to help you analyze T cell immunity. In addition to the T cell lines we have developed, listed above, we can also create custom antigen-specific T cell lines for your research needs.
Developing Assays Using Antigen-Specific T Cells
While we have a basic method for measuring T cell activation in vitro, we also develop custom assays to measure the effects of drugs and antibodies on the immune response.
Do you have an antigen-specific T cell you want to be developed? Contact our research team with your request, or fill out the form below and we will be in touch with you soon to discuss your project in more detail. We’re excited to discover with you!