Useful Tools in Immunology: Catalogue of Somatic Mutations in Cancer

  The Catalogue of Somatic Mutations in Cancer (COSMIC) is the world’s largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.  Why We Love COSMIC 1. The website is an easy, one-stop reference for all information about specific genes and mutations. 2. The cancer browser shows mutations that are […]

Useful Tools in Immunology: The Human Protein Atlas

When I need more information on a protein or antibody, one of the first places I turn to is The Human Protein Atlas. It’s a remarkable open-access collection of all known proteins in human cells, tissues, and organs.  When I say remarkable, I mean it. The Human Protein Atlas has amassed detailed information on more […]

Highlights from the 2019 Cell Symposia Hallmarks of Cancer

This was our first year attending the Cell Symposia Hallmarks of Cancer event held here in Seattle — and boy was it informative! The event brought together some of the world’s leading cancer researchers and oncologists to share the latest from their research and practices.  We got to hear from the likes of Philip Greenburg, […]

Cells in Motion: New Research and Patent Applications

T-Scan: A genome-wide method for the systematic discovery of T cell epitopes Kula et al. describe a new method for discovering T cell epitopes that does not require the culture of T cells and allows for precise mapping of T cells to the peptides they recognize. Astarte Cells Used: PBMC Inhibitory effect of  Acer tegmentosum […]

Mice with Human Immune Systems: A Model for in Vivo Studies

Mice have long been used as a model system for studying the human immune system, from which many basic principles of immunology have been uncovered. As discoveries made using mouse models show promise for therapeutic development for human patients, human-mouse models can serve as an ideal model of the human immune system prior to clinical […]

Introducing T-Scan: A High-Throughput Platform for Identifying Antigens Recognized by T Cells

There is a new method for discovering T cell epitopes, recently detailed in a Cell article, T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. T cell profiling technologies have long been a limitation to our understanding of T cell antigens, something that the creators of T-Scan hope to address.  How T-Scan […]

Immunology for Non-Immunologists: Hot vs. Cold Tumors

Hot, cold, and in-between. Tumors come in all forms — some better targets for immunotherapy treatment than others. This post will help you learn more about hot tumors, cold tumors, and what researchers are doing to make cold tumors more receptive to immunotherapies.  What Are Hot Tumors?  Tumors described as “hot” are those that show […]

Useful Tools in Immunology:

The Online Mendelian Inheritance in ManⓇ website, or OMIMⓇ, is a publicly available catalog of over 15,000 human genes and all known genetic disorders updated daily by the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins University. Intended for physician and research use, OMIM is a searchable index of clinical features, phenotypes, genes, and more. […]

The Yolk Sac Found to be a Second Origin of Endothelial Cells

A recent paper published in Nature, A dual origin for blood vessels, describes experiments that trace the development of endothelial cells in mice. By targeting expression of a fluorescent protein to cells of the yolk sac, Plein et al. were able to show that endothelial cells lining blood vessels develop from two different embryonic cell […]

Useful Tools in Immunology: The Immune Epitope Database

The Immune Epitope Database (IEDB) is a free online resource established by the National Institute for Health. The IEDB makes it easy for scientists and researchers to search for experimental data characterizing antibody and T cell epitopes for allergens, infectious diseases, autoimmune diseases, and transplants/alloantigens. Beyond epitope search, the IEDB also offers unique epitope analysis […]