Now Available: MAGE-A10 Antigen-Specific T Cells

MAGE-A10 is highly expressed in triple-negative breast cancers (Estrogen Receptor / Progesterone Receptor / HER-2-negative), an important focus for many cancer researchers. We have developed a new T cell line specific for the MAGE-A10254-263 peptide (GLYDGMEHL) and restricted by HLA-A*0201. These MAGE-A10 T cells could be the perfect complement to your cancer immunotherapy research. View […]

New: Anti-HER2/neu T Cells for Early Stage Research

What is the HER2 Antigen? HER2 is a tumor-related antigen also known as ERBB2 or NEU. The HER2 gene encodes a human epidermal growth factor receptor (EGFR) that is overexpressed by several tumor types, most notably in breast and ovarian cancers.  Many women (and men) are interested to know their HER2 status. HER2 gene amplification […]

Advantages of Mobilized Stem Cells vs. Bone Marrow Stem Cells

For decades, medical professionals and researchers have relied on and even preferred stem cells derived from bone marrow for transplantation and research purposes. When bone marrow transplantation began in 1956, this was the only way to harness the body’s most versatile cells. In the nearly 65 years since the first successful bone marrow transplant, there […]

In-Depth Guide for Working with Macrophages

Macrophages have many applications in immunology research and can produce a wide range of cytokines and chemokines that can influence the immune response in both mouse and human models.  We’ve compiled an in-depth guide with our best resources for working with macrophages, the “Big Eaters” of the immune system. You’ll get tips for creating and […]

Endotoxin Detection: How Clean Are Your Antigens?

Have you ever spent weeks or months pursuing a mysterious artifact in your culture only to discover that the cause was a reagent or culture media contaminated with bacterial endotoxin? You’re not alone. Continue reading for a cautionary tale on endotoxin contamination. Detecting a Problem: Clueing in on Endotoxin Contamination We encountered an endotoxin contamination […]

The Researcher’s Guide to Utilizing PBMC

Peripheral blood mononuclear cells (PBMC) play a critical role in our understanding of the human immune system and developing life-saving and life-altering treatments. With plays in immunology, inflammation, toxicology, vaccination, and other fields, scientists in all areas need to have a deep understanding of this ready-made blend of innate and adaptive immune cells. We’ve created […]

Could You Benefit from Research-Grade Leukopaks?

Immunology and oncology researchers use leukopaks for a steady supply of effector cells as raw materials for their research and development efforts. Leukopaks are generally collected from healthy donors and shipped fresh overnight, containing between 5 and 20 billion white blood cells depending on the volume of blood processed from the donor during leukapheresis. Leukopaks […]