Cells in Motion: Macrophage Research

research blog post

Macrophages play an important role in immunology, cancer, and inflammatory research. Two recent publications featured cells from Astarte Biologics to study the various effects of macrophages on killing breast cancer cells and impacting reproductive health, respectively.

Macrophage-mediated Trogocytosis Leads to Death of Antibody-opsonized Tumor Cells

Velmurugan, et al. found that trogocytosis was effective in killing HER2-overexpressing breast cancer cells following persistent trogocytic attacks, which was further enhanced by increasing interactions with FcγR-enhanced antibodies.

Astarte Cells Used:

Purified Human Monocytes
Purified Primary Human B Cells

The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality

In a study of the effects of oxidative stress on reproductive outcomes, Shaeib, et al. found that myeloperoxidase (MPO) has a detrimental effect on oocyte quality. These results could impact treatment plans and reproductive technologies for patients with inflammatory conditions.

Astarte Cells Used:

Peritoneal Mouse Macrophage Cells
Peritoneal Mouse Neutrophil Cells

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