Anti Myelin Basic Protein T Cells

Donor #: 3
Size: 1-2M cells/vial
Price: $525.00
In Stock: 57
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Product Details

Blood Type: Unknown
Age: 56
Gender: Male
Ethnicity: Caucasian
Donor Health: Healthy
Anticoagulant: Unknown
HLA-A: 02:01,02:01
HLA-B: 14,27:05
HLA-DRβ 1: 15:01,14

Additional Donor Information:

The BC3 cell line was isolated from a normal 56 year old Caucasian man. In vitro stimulation of peripheral blood mononuclear cells (PBMC) with a peptide of MBP was used to select for peptide reactive T cells. The peptide used (ENPVVHFFKNIVTPRTP) is believed to be the immunodominant epitope. The cell line is likely oligoclonal and recognizes the peptide presented by HLA-DRβ1*1501 and may also recognize peptide presented by HLA-DRβ1*14, though this has not yet been confirmed. The cells also recognize the peptide FFKNIVTPRTPPPSQGK, thus the minimal epitope for this line is FFKNIVTPRTP.
The cells secrete interferon gamma, IL-13 and TNF alpha upon stimulation. They are CD4+ and, not surprisingly, FoxP3 negative.

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