These CD4+ T cells are specific for a peptide (QYIKANSKFIGITEL) derived from tetanus toxoid bound to HLA-DRB1*01. They also recognize whole tetanus toxoid but only when presented by dendritic cells, not B-LCL. The T cells proliferate when stimulated with antigen and APC. They also produce IFNg, IL-5, IL-10, and IL-13.
Healthy female donor, CMV negative. 5′ 10″ tall, 210 lbs. Her genotype at Fc gamma RIII alpha 158 is F/V.