About CD8+ T Cells

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Our CD8+ T cells are purified from PBMC using negative immunomagnetic selection.

CD8+ T cells make up 1/3 of the T cells in peripheral blood and are important in eliminating viruses and tumor cells. CD8+ T cells are quiescent until they encounter a peptide antigen bound to an MHC class I molecule, which are responsible for binding bits of proteins synthesized within each cell.

When a virus infects a cell and directs production of viral proteins, they are presented to CD8+ T cells by MHC class I molecules. The CD8+ T cells respond by dividing to create more antigen-specific CD8+ T cells to fight the infection.

Antigen-Specific CD8+ T Cells are polyclonal T cell lines derived by repeated activation with antigen presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the percentage of antigen reactive cells using HLA-peptide multimers. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.

Naïve CD8+ T Cells are those cells that have not encountered their cognate antigen and do not have a defined function.

Memory CD8+ T Cells are T cells that have previously encountered antigen and have differentiated to central memory or effector memory cells.

Total CD8+ T Cells are isolated from PBMC by negative immunomagnetic selection. They contain both naïve and memory T cells and can be used to derive antigen-specific T cells to your antigen of interest.

We have CD8+ T cells from a variety of donors in a range of vial sizes. All donors are HLA typed and tested negative for blood-borne pathogens.

Publications Using T Cells from Astarte Biologics

Quantifying the cluster of differentiation 4 receptor density on human T lymphocytes using multiple reaction monitoring mass spectrometry. Analytical Chemistry. 2013.

Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010.

Generation of nondividing high rate Ig-secreting plasma cells in cultures of human B cells stimulated with anti-CD3-activated T cells. Journal of Immunology. 1992.