About CD8+ T CellsVIEW PRODUCT LISTING
Our CD8+ T cells are purified from PBMC using negative immunomagnetic selection.
CD8+ T cells make up 1/3 of the T cells in peripheral blood and are important in eliminating viruses and tumor cells. CD8+ T cells are quiescent until they encounter a peptide antigen bound to an MHC class I molecule, which are responsible for binding bits of proteins synthesized within each cell.
When a virus infects a cell and directs production of viral proteins, they are presented to CD8+ T cells by MHC class I molecules. The CD8+ T cells respond by dividing to create more antigen-specific CD8+ T cells to fight the infection.
Antigen-Specific CD8+ T Cells are polyclonal T cell lines derived by repeated activation with antigen presenting cells and peptide antigen. We verify the response of the T cells to the peptide antigen of interest and determine the percentage of antigen reactive cells using HLA-peptide multimers. These T cells can be used in assays on the day they are thawed for ease of use in your experiments.
Naïve CD8+ T Cells are those cells that have not encountered their cognate antigen and do not have a defined function.
Memory CD8+ T Cells are T cells that have previously encountered antigen and have differentiated to central memory or effector memory cells.
Total CD8+ T Cells are isolated from PBMC by negative immunomagnetic selection. They contain both naïve and memory T cells and can be used to derive antigen-specific T cells to your antigen of interest.
We have CD8+ T cells from a variety of donors in a range of vial sizes. All donors are HLA typed and tested negative for blood-borne pathogens.
Publications Using T Cells from Astarte Biologics
Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010.