Comparing Natural and Induced T Regulatory Cells

research blog post

When buying T regulatory cells for autoimmune or immunotherapy research, you have two options: natural T regulatory cells or induced T regulatory cells. The main difference between the two is quite clear. Induced Tregs are differentiated in the lab outside of the thymus, while natural Tregs come directly from the donor’s body. But there are […]

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Does Your Drug Candidate Have Immunotoxicity?

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There are many ways that a drug or biologic therapy can impact the immune system, many of which aren’t discovered in the early stages of drug development. For example, chemotherapies that impede the development of hematopoietic cells can leave cancer patients anemic and prone to infection. So how can you identify the negative immune system […]

Researcher Spotlight: Benjamin Tjoa

Astarte people

Astarte’s scientists bring a wealth of immunology research expertise from diverse backgrounds. With extensive experience in a variety of biologics disciplines, our team is an ideal resource for a wide range of outsource research services. From multiplex assays to flow cytometric analyses, Astarte helps you get on with discovery. In this researcher spotlight, we introduce […]

5 Benefits of Testing with Pooled PBMC

research blog post

1. Eliminate Costly LAL & Rabbit Testing Because their blood clots at the presence of bacterial endotoxins, lysate of horseshoe crab blood (Limulus amoebocyte lysate, LAL) has been used since the 1960s to test pharmaceuticals for substances that can cause fever. The rabbit pyrogen test was more commonly used before the 1960s but is still […]

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How Do I Select a Donor with a Strong Immune Response to Influenza Virus?

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Influenza season is just around the corner. With many Americans expected to seek out the flu vaccination starting in September and October, customers will soon be asking if our donors have received the flu shot or are infected with the flu. We always gather as much information about our donors as possible, and influenza vaccination […]

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How Do I Decode the HLA System?

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Despite being central to adaptive immunity and transplantation, the genetic locus that encodes Human Leukocyte Antigens (HLA) can be confusing to scientists who don’t specialize in it. HLA Background The molecules that belong to the HLA system were first defined using antibodies: the class I antigens (A, B and C) and the class II antigen […]

Functional Testing for T Cell and PBMC Quality Control

research blog post

Proper testing of antigen specific T cells and PBMC is essential to ensure antigen specificity and cell functionality. Whether you’re purchasing human cells for research from a supplier or preparing your own antigen specific T cells or PBMC for experimentation, it’s important to perform the appropriate tests beforehand. At Astarte, we always test our antigen […]

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Why Should I Read the Certificate of Analysis?

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Studying the Certificate of Analysis is a fundamental step to ensuring the immune cell products you purchase are going to be viable, pure, or match the specifications required for your experiment. Let’s face it: even the best purification methods sometimes fail. As a researcher, you need to educate yourself on the purity of the cells […]