Immunology for Non-Immunologists: Cytokine Measurement

What Are Cytokine Measurement Assays? Cytokine measurement assays are sensitive measures for both primary cell assays and purified antigen-specific cultures. Detecting the presence of cytokines — small proteins that are secreted by immune cells to signal an immune or inflammatory response — can help researchers better understand how our bodies respond to invading pathogens. Common […]

Cells in Motion: Recent Patent Applications

Targeted heterodimeric Fc fusion proteins containing IL-15 IL-15alpha and antigen binding domains Bernett, Matthew et al. “The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc fusion protein and an antigen binding domain Fc fusion proteins. In some instances, the antigen binding domain binds to CD8, NKG2A, or […]

What Are Irradiated PBMC? Learn About Our Newest Product.

Sometimes researchers need access to the components and benefits of normal peripheral blood mononuclear cells, but don’t want the cells to proliferate in their experiments. That’s where irradiated PBMC come in handy. Learn more about our newest immune cell product below. What Are Irradiated PBMC? Irradiated PBMC are normal PBMC that have been exposed to […]

What We Learned at AACR 2019

We all know that CAR-T therapies and immune checkpoint inhibitors are game-changers for oncology, and both were on display at the American Association for Cancer Research’s annual meeting held in Atlanta last week. Although both therapies have produced spectacular results in some patients, neither work for all patients and efforts must now turn to understanding […]

Ask A Scientist: Immunology Acronym Confusion

With so many acronyms used in the field of immunology, things can get confusing and mistakes can be costly. Acronyms are useful devices to reduce long, sometimes tongue-twisting terms into manageable shorthand, but do add confusion to those newer to the field.    We’ve cleared up several of these situations through the years via our […]

New Resource for Antigen-Specific T Cells

Antigen-specific T cells are a powerful tool for understanding human immunity and developing treatments and cures for our most prolific diseases. Luckily, they are more readily available to researchers than ever before. Not only have we devoted many resources over the past several years to developing an exclusive inventory of antigen-specific T cells for use […]

Using Anti-MART-1 T Cells for Melanoma Immunotherapy Research

MART-1 (melanoma antigen recognized by T cells 1) is a “widely shared melanoma antigen recognized by the T lymphocytes of patients with established malignancy.” MART-1 is one of the oldest identified tumor antigens and is a protein found on normal melanocytes in the skin and retina. It is also found in most melanomas, cancers that […]

Immunology for Non-Immunologists: Innate vs. Adaptive Immunity

Scientific studies directly or indirectly involving human immunity require an understanding of both sides of the complex system. Even the development of an adaptive antigen-specific cell-based therapy requires components of the innate immune system that work in concert with the adaptive cells. If you don’t work primarily in immunology, this post will give you a […]

The Yolk Sac Found to be a Second Origin of Endothelial Cells

A recent paper published in Nature, A dual origin for blood vessels, describes experiments that trace the development of endothelial cells in mice. By targeting expression of a fluorescent protein to cells of the yolk sac, Plein et al. were able to show that endothelial cells lining blood vessels develop from two different embryonic cell […]