Publications

Scientists choose Astarte Biologics’ cells for quality and reliability. View the published articles below to read how scientists are using our cells for research.

 

PBMC

Bispecific SCFV Immunofusion (BIF). 2018.

Modified IL-2 variants that selectively activate regulatory T cells. 2018.

Monocyte function in patients with myelodysplastic syndrome. Journal of Leukocyte Biology. 2018.

Gene array analysis of PD-1H overexpressing monocytes reveals a pro-inflammatory profile. Heliyon. 2018.

Anti-TIGIT antigen-binding proteins and methods of use thereof. 2017.

TLR8 ligation induces apoptosis of monocytic myeloid-derived suppressor cells. Journal of Leukocyte Biology. 2017.

A DNA vaccine protects human immune cells against Zika Virus infection in humanized mice. EBioMedicine. 2017.

Natural killer T cell-targeted immunotherapy mediating long-term memory responses and strong antitumor activity. Frontiers in Immunology. 2017.

PTHrP (12-48) modulates the bone marrow microenvironment and suppresses human osteoclast differentiation and lifespan. Journal of Bone and Mineral Research. 2017.

Dosage and administration of non-fucosylated anti-CD40 antibodies. 2017.

Hepatitis C virus upregulates B-cell receptor signaling: A novel mechanism for HCV-associated B-cell lymphoproliferative disorders. Oncogene. 2015.

Pharmaceutical compounds targeted by MIF affinity-tethered moieties. 2015.

Human monoclonal antibodies to programmed death ligand 1 (PD-L1). 2015.

In vitro characterization of the anti-PD-1 antibody Nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunology Research. 2014.

Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression. Genes and Immunity. 2013

Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells. PLOS ONE. 2013.

Gadolinium contrast agent-induced CD163+ ferroportin+ osteogenic cells in nephrogenic systemic fibrosis. American Journal of Pathology. 2013.

The design, selection, and evaluation of highly specific and functional siRNA incorporating unlocked nucleobase analogs. Methods in Molecular Biology. 2013.

cDNA normalization by hydroxyapatite chromatography to enrich transcriptome diversity in RNA-seq applications. BioTechniques. 2012.

LXR-mediated inhibition of CD4+ T helper cells. PLOS ONE. 2012.

Engineering a CD123xCD3 bispecific scFv immunofusion for the treatment of leukemia and elimination of leukemia stem cells. Protein Engineering Design and Selection. 2012.

HIV-1 co-infection and morphine co-exposure severely dysregulate HCV-induced hepatic pro-inflamatory cytokine release and free radical production: Increased pathogenesis coincides with uncoordinated host-defenses. Journal of Virology. 2011.

PLTP regulates STAT3 and NFκB in Differentiated THP-1 cells and human monocyte-derived macrophages. Biochimica et Biophysica Acta (BBA). 2011.

Potent and systematic RNAi mediated silencing with single oligonucleotide compounds. RNA. 2011.

Iron chelators of the DpT and BpT series inhibit HIV-1 transcription: Identification of novel cellular targets — Iron, CDK2 and CDK9. Molecular Pharmacology. 2010.

Novel adenovirus vectors “capsid-displaying” a human complement inhibitor. Journal of Innate Immunity. 2010.

Novel cancer vaccine based on genes of Salmonella pathogenicity island 2. International Journal of Cancer. 2010.

Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. Journal of Clinical Investigation. 2009.

A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of β-catenin/GSK3 signaling. PLOS ONE. 2009.

Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma. Journal of Clinical Investigation. 2007.

 

Monocytes

Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages. Traffic. 2018.

Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARg/RXR and RAR/RXR: Downregulation of CYP27A1-LXRα signaling. Biochemical Journal. 2018.

Crown-like structures as a biomarker for cancer risk and cancer prognosis. 2013.

Identification of palmitoyl protein thioesterase 1 in human THP-1 monocytes/macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry. 2013.

Transcriptional profiling and pathway analysis of CSF-1 and IL-34 effects on human monocyte differentiation. Cytokine. 2013.

Activating mutations in β-Catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PLOS ONE. 2012.

NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against Gram-negative bacterial infection. Journal of Immunology. 2012.

Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discovery. 2012.

Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. Journal of the American College of Cardiology. 2011.

Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prevention Research. 2011.

Hepcidin induces HIV-1 transcription inhibited by ferroportin. Retrovirology. 2010.

Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of snail in tumor cells. PLOS ONE. 2010.

The EBV-encoded dUTPase activates NF-kB through the TLR2 and MyD88-dependent signaling pathway. Journal of Immunology. 2009.

The NF-kB/AKT-dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1B. Cancer Microenvironment. 2009.

Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: A crosstalk interrupted by vitamin D3. Oncogene. 2009.

 

Autoimmune PBMC and Plasma

Interferon alpha and omega antibody antagonists. 2015.

Systematic identification of novel SLE related autoantibodies responsible for Type I IFN production in human plasmacytoid dendritic cells. Cellular Immunology. 2013.

 

Mouse Dendritic Cells

Adaptor protein-1 (AP-1) promotes cross-presentation through the same tyrosine signal in MHC-I that is targeted by HIV-1. Journal of Virology. 2013.

Negatively charged liposomes show potent adjuvant activity when simply admixed with protein antigens. Molecular Pharmaceutics. 2011.

 

Mouse Bone Marrow Cells

Adaptor protein-1 (AP-1) promotes cross-presentation through the same tyrosine signal in MHC-I that is targeted by HIV-1. Journal of Virology. 2013.

 

Neutrophils

Increased mortality in mice following immunoprophylaxis therapy with high 2 dosage of nicotinamide in Burkholderia persistent infections. Infection and Immunity. 2018.

 

Proteoglycan Kits

Supplementation of specific carbohydrates results in enhanced deposition of chondrogenic-specific matrix during mesenchymal stem cell differentiation. Journal of Tissue Engineering and Regenerative Medicine. 2018.

Labisia pumila prevented osteoarthritis cartilage degeneration by attenuating joint inflammation and collagen breakdown in postmenopausal rat model. Inflammopharmacology. 2018.

Scopoletin-standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study. Phytotherapy Research. 2017.

Effect of chondroitin sulfate on siRNA biodistribution and gene silencing effect in mice after injection of siRNA lipoplexes. Journal of Drug Delivery Science and Technology. 2017.

Comparison of chondrocytes produced from adipose tissue–derived stem cells and cartilage tissue. Journal of Craniofacial Surgery. 2013.

Solubilization of antigen components for removal from tissues. 2013.

Annexin 6 interacts with p65 and stimulates NF‐κB activity and catabolic events in articular chondrocytes. Arthritis & Rheumatology. 2013.

Effect of a herbal-leucine mix on the IL-1beta-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC Complementary and Alternative Medicine. 2011.

 

Lipopolysaccharides (LPS)

Converging findings from linkage between periodontal pathogen with atopic and allergic immune response. Cytokine. 2018.

Modulating toll-like receptor-mediated inflammatory responses following exposure of whole cell and lipopolysaccharide component from Porphyromonas gingivalis in wistar rat models. European Journal of Dentistry. 2017.

Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells. PLOS ONE. 2017.

Modulation of host defense peptide-mediated human mast cell activation by LPS. Innate Immunity. 2015.

Variants of porphyromonas gingivalis lipopolysaccharide alter lipidation of autophagic protein, microtubule–associated protein 1 light chain 3, LC3. Molecular Oral Microbiology. 2015.

Porphyromonas gingivalis stimulates IL-18 secretion in human monocytic THP-1 cells. Microbes and Infection. 2012.

Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Veterinary Immunology and Immunopathology. 2012.

 

B Cells

The downregulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood. 2012.

 

Stem Cells

Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation. Toxicology and Applied Pharmacology. 2017.

 

Human Umbilical Vein Endothelial Cells (HUVEC)

Biocompatibility and inflammation profile of B2A-coated granules used in arthrodesis. International Journal of Toxicology. 2013.

 

Antigen-Specific T Cells

CUE-101, a novel Fc fusion protein for selective targeting and expansion of anti-tumor T cells for treatment of HPV-driven malignancies. 2018.

Checkpoint regulator antagonists. 2018.

Generation and analysis of human T cell lines responsive to Glatiramer Acetate. Cell Reports. 2018.

 

CD3+ T Cells

Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation. Scientific Reports. 2018.

Automated expansion of primary human T cells in scalable and cell‐friendly hydrogel microtubes for adoptive immunotherapy. Advanced Healthcare Materials. 2018.

An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. Journal for ImmunoTherapy of Cancer. 2018.

MNK controls mTORC1:substrate association through regulation of TELO2 binding with mTORC1. Cell Reports. 2017.

 

CD4+ T Cells

Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases. 2017.

Quantifying CD4 receptor density on human T lymphocytes using multiple reaction monitoring mass spectrometry. Analytical Chemistry. 2013.

 

BC3 T Cell Lines

Tunable Variant Immunoglobulin Superfamily Domains and Engineered Cell Therapy. 2018.

Immunomodulatory proteins with tunable affinities. 2018.

ICOS ligand variant immunomodulatory proteins and uses thereof. 2017.

Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis. Journal of Immunology. 2013.

 

Tetanus Toxoid

Antibodies to human programmed death receptor pd-1. 2018.

Antibodies to TIGIT. 2017.

PVRIG polypeptides and methods of treatment. 2017.

Anti-PVRIG antibodies and methods of use. 2017.

 

Bovine Chondrocytes

Hybrid hyaluronic acid hydrogel/poly (ε‐caprolactone) scaffold provides mechanically favorable platform for cartilage tissue engineering studies. Journal of Biomedical Materials Research Part A. 2013.